Great Nef
The Great Nef, first mentioned in The Colour of Magic is an incredibly dry desert, to the point it has negative rainfall. The Great Nef is home to the Dehydrated Ocean, which consists of water in an uncommon fourth state (it dehydrates, leaving a silvery mildew-like freeflowing sand), and Light Dams, which dam up and save the Discworld's slow-moving, syrup-like light.
Nef is "fen" (swamp) backwards, an entirely appropriate name for a desert.
Annotation
Is this a Roundworld reference to the Grand Erg in the Sahara?
Appearances
Mentioned in The Colour of Magic